Abstract
Objective
We examined the relationship between trimester of SARS-CoV-2 infection, illness severity, and risk for preterm birth.
Study design
We analyzed data for 6336 pregnant persons with SARS-CoV-2 infection in 2020 in the United States. Risk ratios for preterm birth were calculated for illness severity, trimester of infection, and illness severity stratified by trimester of infection adjusted for age, selected underlying medical conditions, and pregnancy complications.
Result
Pregnant persons with critical COVID-19 or asymptomatic infection, compared to mild COVID-19, in the second or third trimester were at increased risk of preterm birth. Pregnant persons with moderate-to-severe COVID-19 did not show increased risk of preterm birth in any trimester.
Conclusion
Critical COVID-19 in the second or third trimester was associated with increased risk of preterm birth. This finding can be used to guide prevention strategies, including vaccination, and inform clinical practices for pregnant persons.
【초록키워드】 COVID-19, vaccination, SARS-COV-2 infection, Infection, risk, Pregnancy, Preterm birth, asymptomatic infection, Mild, complications, age, Critical, Clinical practice, pregnant, risk ratio, Medical conditions, Illness severity, increased risk, moderate-to-severe COVID-19, The United States, objective, Result, selected, analyzed, examined, can be used, calculated, adjusted, stratified, 【제목키워드】 Infection, coronavirus 2, pregnant, acute respiratory syndrome,