Abstract
T cells can contribute to clearance of respiratory viruses that cause acute-resolving infections such as SARS-CoV-2, helping to provide long-lived protection against disease. Recent studies have suggested an additional role for T cells in resisting overt infection: pre-existing cross-reactive responses were preferentially enriched in healthcare workers who had abortive infections1, and in household contacts protected from infection2. We hypothesize that such early viral control would require pre-existing cross-reactive memory T cells already resident at the site of infection; such airway-resident responses have been shown to be critical for mediating protection after intranasal vaccination in a murine model of SARS-CoV3. Bronchoalveolar lavage samples from the lower respiratory tract of healthy donors obtained before the COVID-19 pandemic revealed airway-resident, SARS-CoV-2-cross-reactive T cells, which correlated with the strength of human seasonal coronavirus immunity. We therefore demonstrate the potential to harness functional airway-resident SARS-CoV-2-reactive T cells in next-generation mucosal vaccines.
【초록키워드】 SARS-CoV-2, vaccination, Vaccines, T cells, COVID-19 pandemic, Infection, healthcare worker, T cell, response, murine model, household contact, disease, Critical, memory T cell, intranasal, mucosal, Lower respiratory tract, cross-reactive, viral control, clearance, recent, helping, healthy donor, shown, respiratory virus, functional, contribute, suggested, correlated, coronavirus immunity, 【제목키워드】 SARS-CoV-2, T cell, individual,