Abstract
Study design
Focused literature review.
Objectives
Objective of the study was to perform a literature search and summarise the clinical features and prognosis of persons with spinal cord injury (SCI) infected with COVID-19 from the published articles.
Setting
India.
Methods
PubMed, CENTRAL and MEDLINE were systematically searched using specific keywords. The study assessed 2747 scientific studies involving COVID-19 and SCI for possible inclusion in a meta-analysis of SCI and SARS-COV-2. Studies involving persons with SCI who were tested positive for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in the nasopharyngeal or throat swab polymerase chain reaction were included.
Results
Out of 2747 articles, 11 articles (206 participants), including six case reports, were included in this review. Fever was the most frequently observed symptom of COVID-19 infection in the SCI population. C-reactive protein (CRP) and lymphocytopenia were common abnormal laboratory parameters. The most common radiological finding in COVID-19 infection was ground glass opacities in lung fields. Prophylactic/therapeutic anticoagulation was given in a significant number of SCI persons infected with COVID-19. Persons with SCI who were diagnosed early showed good outcomes.
Conclusions
Based on the few studies published on COVID-19 and SCI populations since 2019, this study determined fever, elevated CRP, lymphocytopenia and ground glass opacities, which indicated inflammation, compromised immune response, and lung edema, as the main clinical features of COVID-19 infection in SCI population. Though COVID-19 infection reported an increased number of deaths in few studies, a significant number of SCI populations with positive RT-PCR were treated successfully and discharged at home.
【초록키워드】 COVID-19, Meta-analysis, SARS-CoV-2, Inflammation, immune response, anticoagulation, Prognosis, India, lung, CRP, Symptom, Population, outcomes, COVID-19 infection, nasopharyngeal, lymphocytopenia, ground glass opacities, Fever, death, Laboratory parameters, clinical feature, Coronavirus-2, positive RT-PCR, Spinal cord injury, C-reactive protein (CRP, literature review, Ground glass opacity, acute respiratory syndrome, Participants, article, positive, throat swab, lung edema, Inclusion, objective, articles, setting, radiological finding, polymerase chain, Result, tested, reported, indicated, diagnosed, elevated, treated, searched, discharged, infected with COVID-19, Person, 【제목키워드】 Prognosis, Infection, clinical, feature,