Abstract
This study sought to determine whether a foot–ankle therapeutic exercise program can improve daily physical activity (i.e. number of steps) and fast and self-selected gait speed in people with diabetic peripheral neuropathy (DPN). In this single-blind randomized controlled trial and intention-to-treat analysis, 78 volunteers with DPN were allocated into a control group, which received usual care, and an intervention group (IG), which received usual care plus a 12-week foot–ankle exercise program. The adherence at 12 weeks rate in the IG was 92.3% (36 participants) and the dropout was 5.1% in the control group (2 participants). The number of steps and self-selected gait speed did not change significantly in either group (p > 0.05), although a 1,365-step difference between groups were observed at 1-year followup. The 12-week foot–ankle therapeutic exercises improved significantly fast-gait speed (primary outcome) (p = 0.020), ankle range of motion (p = 0.048), and vibration perception (secondary outcomes) (p = 0.030), compared with usual-care at 12 weeks. At 24 weeks, the IG showed better quality of life than controls (p = 0.048). At 1-year, fast-gait speed and vibration perception remained higher in the IG versus controls. Overall, the program may be a complementary treatment strategy for improving musculoskeletal and functional deficits related to DPN.
Trial registration ClinicalTrials.gov NCT02790931 (06/06/2016).
【초록키워드】 Randomized controlled trial, Treatment, physical activity, therapeutic, Control, Quality of life, group, complementary, Diabetic, Musculoskeletal, Participants, Primary outcome, control group, intervention group, Secondary outcomes, usual care, single-blind, intention-to-treat analysis, Volunteer, controls, IMPROVE, significantly, remained, functional, determine, gait speed, 【제목키워드】 Randomized controlled trial, therapeutic, Diabetic, IMPROVE, gait speed,