Neurofilament Light Chain as a Biomarker of Neuronal Damage in Children With Malaria

Published on
Journal: Nanoscale
[저자] Núria Balanza, Caroline K Francis, Valerie M Crowley, Andrea M Weckman, Kathleen Zhong, Bàrbara Baro, Rosauro Varo, Quique Bassat, Kevin C Kain, Rosiglitazone Adjunctive Therapy for Severe Malaria in Children (ROSI) Study Group
[Category] 말라리아,
Pubmed URL    DOI URL    
[Source] pubmed

Malaria can cause brain injury. Neurofilament light chain (NfL) is a biomarker of neuronal damage. Here we examined longitudinal plasma NfL levels in children aged 1-12 years with uncomplicated and severe malaria from Mozambique. NfL levels were similar in all malaria cases at hospital admission. However, levels increased over time and the increment was significantly higher in severe malaria cases with neurological manifestations (ie, coma, impaired consciousness, or repeated seizures). NfL may be useful to identify and quantify brain injury in malaria.

All Keywords
【저자키워드】 Biomarker, malaria, brain injury, neurofilament light chain, neuronal damage.,