Abstract
A recent genetic association study1 identified a gene cluster on chromosome 3 as a risk locus for respiratory failure after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A separate study (COVID-19 Host Genetics Initiative)2 comprising 3,199 hospitalized patients with coronavirus disease 2019 (COVID-19) and control individuals showed that this cluster is the major genetic risk factor for severe symptoms after SARS-CoV-2 infection and hospitalization. Here we show that the risk is conferred by a genomic segment of around 50 kilobases in size that is inherited from Neanderthals and is carried by around 50% of people in south Asia and around 16% of people in Europe.
All Keywords
【초록키워드】 COVID-19, coronavirus disease, SARS-CoV-2, coronavirus, Europe, Respiratory failure, Hospitalization, SARS-COV-2 infection, Genetic, Infection, risk, Asia, Cluster, genomic, association, acute respiratory syndrome, locus, chromosome, individual, Neanderthal, gene cluster, genetic risk factor, carried, hospitalized patient, severe symptom, 【제목키워드】 severe COVID-19, Neanderthal, genetic risk factor,
【초록키워드】 COVID-19, coronavirus disease, SARS-CoV-2, coronavirus, Europe, Respiratory failure, Hospitalization, SARS-COV-2 infection, Genetic, Infection, risk, Asia, Cluster, genomic, association, acute respiratory syndrome, locus, chromosome, individual, Neanderthal, gene cluster, genetic risk factor, carried, hospitalized patient, severe symptom, 【제목키워드】 severe COVID-19, Neanderthal, genetic risk factor,