Abstract
Using online surveys, we collected data regarding COVID-19-related loss of smell or taste from 69,841 individuals. We performed a multi-ancestry genome-wide association study and identified a genome-wide significant locus in the vicinity of the UGT2A1 and UGT2A2 genes. Both genes are expressed in the olfactory epithelium and play a role in metabolizing odorants. These findings provide a genetic link to the biological mechanisms underlying COVID-19-related loss of smell or taste.
All Keywords
【초록키워드】 Genome-wide association study, mechanism, Olfactory epithelium, Loss of Smell, locus, collected data, genetic link, Genes, performed, expressed, individuals, genome-wide significant, UGT2A1, UGT2A2, 【제목키워드】 Loss of Smell, locus,
【초록키워드】 Genome-wide association study, mechanism, Olfactory epithelium, Loss of Smell, locus, collected data, genetic link, Genes, performed, expressed, individuals, genome-wide significant, UGT2A1, UGT2A2, 【제목키워드】 Loss of Smell, locus,