Effect of Body Weight and Age on the Pharmacokinetics of Dihydroartemisinin: Food and Drug Administration Basis for Dose Determination of Artesunate for Injection in Pediatric Patients With Severe Malaria

Published on
Journal: Clinical infectious diseases : an official publication of the Infectious
[저자] Eliford Kitabi, Timothy J Bensman, Justin C Earp, Dakshina M Chilukuri, Heidi Smith, Leslie Ball, Elizabeth O'Shaughnessy, Yuliya Yasinskaya, Philip M Colangelo, Kellie S Reynolds
[Category] 말라리아,
Pubmed URL    DOI URL    
[Source] pubmed

For treatment of severe malaria, the World Health Organization recommends 3 mg/kg intravenous artesunate in pediatric patients weighing less than 20 kg. Here we describe the Food and Drug Administration’s rationale for selecting 2.4 mg/kg in pediatric patients weighing less than 20 kg based on literature review and independent analyses.

All Keywords
【저자키워드】 artesunate, severe malaria, dihydroartemisinin, pediatric dose selection, pharmacokinetic modeling and simulation,