We measured susceptibilities of Ugandan Plasmodium falciparum isolates assayed on the day of collection or after storage at 4°C. Samples were incubated with serial dilutions of 8 antimalarials, and susceptibilities were determined from 72-h growth inhibition assays. Storage was associated with decreased growth and lower 50% inhibitory concentration values, but differences between assays beginning on day 0 or after 1 or 2 days of storage were modest, indicating that short-term storage before drug susceptibility determination is feasible.
All Keywords
【저자키워드】 Uganda, malaria, Antimalarials, cold storage, Plasmodium falciparum, Ex vivo, growth, drug susceptibility,
【저자키워드】 Uganda, malaria, Antimalarials, cold storage, Plasmodium falciparum, Ex vivo, growth, drug susceptibility,