γδ T cells are essential for eliminating Plasmodium berghei XAT. Because administration of the agonistic anti-CD40 antibody can induce elimination of P. berghei XAT parasites in γδ T cell-deficient mice, we considered that γδ T cells might activate dendritic cells via CD40 signalling during infection. Here we report that administration of the anti-CD40 antibody to γδ T cell-deficient mice 3-10 days post-P. berghei XAT infection could eliminate the parasites. Our data suggest that dendritic cell activation via γδ T cells expressing CD40 ligand is critical during the early phase of infection.
All Keywords
【저자키워드】 dendritic cells, malaria, CD40 ligand, γδ T cells, CD40 signalling,
【저자키워드】 dendritic cells, malaria, CD40 ligand, γδ T cells, CD40 signalling,