The RTS,S/AS02A malaria vaccine is based on the Plasmodium falciparum circumsporozoite protein (PfCSP), which is O-fucosylated on the sporozoite surface. We determined whether RTS,S/AS02A-induced immunoglobulin G (IgG) antibodies recognize vaccine-like nonfucosylated PfCSP better than native-like fucosylated PfCSP. Similar to previous vaccine trials, RTS,S/AS02A vaccination induced high anti-PfCSP IgG levels associated with malaria protection. IgG recognition of nonfucosylated and fucosylated PfCSP was equivalent, suggesting that PfCSP fucosylation does not affect antibody recognition. Clinical Trials Registration. NCT00197041 .
All Keywords
【저자키워드】 antibodies, immunogenicity, malaria, Plasmodium falciparum, fucosylation, RTS,S, circumsporozoite protein (PfCSP),
【저자키워드】 antibodies, immunogenicity, malaria, Plasmodium falciparum, fucosylation, RTS,S, circumsporozoite protein (PfCSP),