Abstract
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells’ potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.
【초록키워드】 SARS-CoV-2, viral infection, Innate immunity, Spread, SARS-CoV-2 transmission, resource, expression, COVID-19 patient, Efficiency, Single-cell RNA-sequencing, clearance, intestinal epithelial cells, offer, inquiry, transcript, Corneal, initial, clinical sample, involved, healthy, investigated, co-expressed, highlighting, human donors, multiple tissue, nasal epithelial cell, 【제목키워드】 SARS-CoV-2 entry factor, expressed, innate immune gene, nasal epithelial cell,