Abstract
We engineered three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70-deletion + N501Y + D614G from UK; and E484K + N501Y + D614G from SA. Neutralization geometric mean titers (GMTs) of 20 BTN162b2 vaccine-elicited human sera against the three mutant viruses were 0.81- to 1.46-fold of the GMTs against parental virus, indicating small effects of these mutations on neutralization by sera elicited by two BNT162b2 doses.
All Keywords
【초록키워드】 SARS-CoV-2, coronavirus, Mutation, neutralization, virus, BNT162b2, spike mutation, N501Y, sera, African, United Kingdom, mutant virus, acute respiratory syndrome, GMTs, South, human sera, doses, geometric mean titer, Effect, elicited, parental, GMT, 【제목키워드】 variant, BNT162b2, N501Y, sera, E484K, SARS-CoV-2 spike,
【초록키워드】 SARS-CoV-2, coronavirus, Mutation, neutralization, virus, BNT162b2, spike mutation, N501Y, sera, African, United Kingdom, mutant virus, acute respiratory syndrome, GMTs, South, human sera, doses, geometric mean titer, Effect, elicited, parental, GMT, 【제목키워드】 variant, BNT162b2, N501Y, sera, E484K, SARS-CoV-2 spike,