Coronavirus disease 2019 (COVID-19) is a pandemic viral disease originated in Wuhan, China, in December 2019, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The severe form of the disease is often associated with acute respiratory distress syndrome (ARDS), and most critically ill patients require mechanical ventilation and support in intensive care units. A significant portion of COVID-19 patients also develop complications of the cardiovascular system, primarily acute myocardial injury, arrhythmia, or heart failure. To date, no specific antiviral therapy is available for patients with SARS-CoV-2 infection. Exosomes derived from mesenchymal stem cells (MSCs) are being explored for the management of a number of diseases that currently have limited or no therapeutic options, thanks to their anti-inflammatory, immunomodulatory, and pro-angiogenic properties. Here, we briefly introduce the pathogenesis of SARS-CoV-2 and its implications in the heart and lungs. Next, we describe some of the most significant clinical evidence of the successful use of MSC-derived exosomes in animal models of lung and heart injuries, which might strengthen our hypothesis in terms of their utility for also treating critically ill COVID-19 patients.
【저자키워드】 COVID-19, coronavirus, immunomodulation, Anti-inflammation, angiotensin-converting enzyme 2, acute lung injury, acute myocardial injury, mesenchymal stem cell-derived exosomes, 【초록키워드】 SARS-CoV-2, Exosome, antiviral therapy, Coronavirus disease 2019, ARDS, pandemic, Anti-inflammatory, mechanical ventilation, Infection, lung, MSCs, animal model, cardiovascular system, arrhythmia, heart failure, intensive care units, myocardial injury, Critically ill, management, Lungs, immunomodulatory, Complication, viral disease, utility, disease, COVID-19 patients, therapeutic options, acute respiratory distress, Hypothesis, COVID-19 patient, stem cell, Support, Critically ill patient, acute respiratory syndrome, syndrome, clinical evidence, pathogenesis of SARS-CoV-2, implication, Wuhan, China, develop, caused, the disease, patients with SARS-CoV-2, 【제목키워드】 Exosome, option, STEM, Ill,