Abstract
The aim of this study was to identify factors associated with the death of patients with COVID-19 pneumonia caused by the novel coronavirus SARS-CoV-2.All clinical and laboratory parameters were collected prospectively from a cohort of patients with COVID-19 pneumonia who were hospitalised to Wuhan Pulmonary Hospital (Wuhan City, Hubei Province, China) between 25 December 2019 and 7 February 2020. Univariate and multivariate logistic regression analysis revealed that age ≥65 years (OR 3.765, 95% CI 1.146–17.394; p=0.023), pre-existing concurrent cardiovascular or cerebrovascular diseases (OR 2.464, 95% CI 0.755–8.044; p=0.007), CD3+CD8+ T-cells ≤75 cells·μL−1 (OR 3.982, 95% CI 1.132–14.006; p<0.001) and cardiac troponin I ≥0.05 ng·mL−1 (OR 4.077, 95% CI 1.166–14.253; p<0.001) were associated with an increase in risk of mortality from COVID-19 pneumonia.” has been corrected to: “Univariate and multivariate logistic regression analysis revealed that age ≥65 years (OR 3.765, 95% CI 1.201−11.803; p=0.023), pre-existing concurrent cardiovascular or cerebrovascular diseases (OR 2.464, 95% CI 1.279−4.747; p=0.007), CD3+CD8+ T-cells ≤75 cells·μL−1 (OR 3.982, 95% CI 1.761–9.004; p<0.001) and cardiac troponin I ≥0.05 ng·mL−1 (OR 4.077, 95% CI 1.778–9.349; p<0.001) were associated with an increase in risk of mortality from COVID-19 pneumonia. In a sex-, age- and comorbid illness-matched case-control study, CD3 + CD8 + T-cells ≤75 cells·μL -1 and cardiac troponin I ≥0.05 ng·mL -1 remained as predictors for high mortality from COVID-19 pneumonia.We identified four risk factors: age ≥65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3 + CD8 + T-cells ≤75 cells·μL -1 and cardiac troponin I ≥0.05 ng·mL -1 The latter two factors, especially, were predictors for mortality of COVID-19 pneumonia patients.
【초록키워드】 COVID-19, Mortality, Pneumonia, risk, CD8, pulmonary, Novel coronavirus, cardiac troponin, China, Wuhan, Factors, death, age, predictor, T-cell, case-control study, Analysis, Cerebrovascular disease, cerebrovascular diseases, Factor, 95% CI, city, multivariate logistic regression, high mortality, COVID-19 pneumonia patients, hospitalised, CD3, laboratory parameter, CD3+CD8+, identify, collected, caused, remained, increase in, cohort of patient, patients with COVID-19, sex-, with COVID-19, 【제목키워드】 Mortality, Pneumonia, prospective cohort study, caused, patients with COVID-19,