Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is a novel virus that has been identified as a causal agent of COVID-19, an emergent infectious disease which brought about a new pandemic in the 21 st century. The immune responses and clinical features of individuals infected with SARS-CoV-2 have not yet been fully described. Thus, in this study, we compare the seroprevalence and define the correlation between symptoms and serological results in the first COVID-19 cluster in the city of Konjic, Bosnia, and Herzegovina. Of the total number, 93% of real-time polymerase chain reaction-positive participants had positive immunoglobulin G (IgG) serology and 75% of them developed symptoms of COVID-19. We found that there was no significant alteration in specific IgG ( p = 0.504) antibody levels during the 1-year period after COVID-19. Our results indicate that symptomatic COVID-19 patients have a higher rate of seroconversion ( p < 0.01). The IgG seroconversion was correlated with high fever ( p = 0.002) and headache ( p = 0.007), suggesting that these symptoms could be considered as indicators of a better immune response. This study has demonstrated persistence of sustained levels of specific SARS-CoV-2 antibodies after recovering from COVID-19 infection. However, to gain a better insight into the immune response to SARS-CoV-2, further systematic studies should be focused on quality and longevity analyses.
【저자키워드】 COVID-19, IgG, immune response, pandemic, Seroconversion, Bosnia and Herzegovina, Severe acute respiratory syndrome coronavirus type 2, 【초록키워드】 SARS-CoV-2, coronavirus, serology, antibody, Infection, Symptom, Infectious disease, headache, virus, SARS-CoV-2 antibody, Immunoglobulin, persistence, symptomatic, Fever, Cluster, correlation, clinical feature, COVID-19 patient, acute respiratory syndrome, individual, participant, symptoms of COVID-19, positive, polymerase chain, described, demonstrated, correlated, analyses, sustained, infected with SARS-CoV-2, rate of seroconversion, recovering from COVID-19, serological result, these symptom, 【제목키워드】 SARS-CoV-2 antibody, Cluster,