Introduction: Aim of this study is to analyse the characteristics of ventilator-associated pneumonia (VAP) inpatients infected by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). Materials and Methods: A retrospective study was conducted, including coronavirus infectious disease 2019 (COVID-19) patients who developed VAP from March to May 2020 (VAP COVID-19). They were compared to non-COVID-19 patients who developed VAP from January 2011 to December 2019 (VAP NO COVID-19) and COVID-19 patients who did not develop VAP (NO VAP COVID-19). Results: Overall, 42 patients were included in the VAP COVID-19group, 37 in the NO VAP COVID-19 group, and 188 in the VAP NO COVID-19 group. VAP COVID-19 had significantly higher rates of shock (71% vs. 48%, p = 0.009), death in ICU (52% vs. 30%, p = 0.011), VAP recurrence (28% vs. 4%, p < 0.0001), positive blood culture (26% vs. 13%, p = 0.038), and polymicrobial culture (28% vs. 13%, p = 0.011) than VAP NO COVID-19. At the multivariate analysis, death in patients with VAP was associated with shock ( p = 0.032) and SARS-CoV-2 ( p = 0.008) infection. Conclusions: VAP in COVID-19 patients is associated with shock, bloodstream, and polymicrobial infections.
【저자키워드】 Coronavirus infectious disease 2019, Ventilator-associated pneumonia, blood culture, polymicrobial culture, severe acute respiratory syndrome-coronavirus 2, 【초록키워드】 COVID-19, SARS-CoV-2, coronavirus, Infection, Infectious disease, ICU, Retrospective study, Shock, infections, Characteristics, Culture, Patient, death, Blood, Analysis, COVID-19 patient, Inpatient, bloodstream, COVID-19 group, material, positive, VAP, develop, conducted, significantly higher, non-COVID-19 patient, 【제목키워드】 COVID-19,