Background An increased susceptibility to COVID-19 has been suggested for individuals with neurodegenerative diseases, but data are scarce from longitudinal studies. Methods In this community-based cohort study, we included 96,275 participants of the UK Biobank who had available SARS-CoV-2 test results in Public Health England. Of these, 2617 had a clinical diagnosis of neurodegenerative diseases in the UK Biobank inpatient hospital data before the outbreak of COVID-19 (defined as January 31st, 2020), while the remaining participants constituted the reference group. We then followed both groups from January 31st, 2020 to June 14th, 2021 for ascertainment of COVID-19 outcomes, including any COVID-19, inpatient care for COVID-19, and COVID-19 related death. Logistic regression was applied to estimate the association between neurogenerative disease and risks of COVID-19 outcomes, adjusted for multiple confounders and somatic comorbidities. Results We observed an elevated risk of COVID-19 outcomes among individuals with a neurodegenerative disease compared with the reference group, corresponding to a fully adjusted odds ratio of 2.47 (95%CI 2.25–2.71) for any COVID-19, 2.18 (95%CI 1.94–2.45) for inpatient COVID-19, and 3.67 (95%CI 3.11–4.34) for COVID-19 related death. Among individuals with a positive test result for SARS-CoV-2, individuals with neurodegenerative diseases had also a higher risk of COVID-19 related death than others (fully adjusted odds ratio 2.08; 95%CI 1.71–2.53). Conclusion Among UK Biobank participants who received at least one test for SARS-CoV-2, a pre-existing diagnosis of neurodegenerative disease was associated with a subsequently increased risk of COVID-19, especially COVID-19 related death. Supplementary Information The online version contains supplementary material available at 10.1186/s12883-021-02536-7.
【저자키워드】 COVID-19, UK biobank, cohort study, Neurodegenerative diseases, 【초록키워드】 SARS-CoV-2, Diseases, susceptibility, hospital, Comorbidities, Diagnosis, risk, outcome, outcomes, outbreak, Longitudinal studies, death, disease, Clinical diagnosis, Care, association, adjusted odds ratio, supplementary material, 95%CI, higher risk, increased risk, individual, participant, positive test result, Public Health England, SARS-CoV-2 test, risk of COVID-19, confounder, Result, defined, elevated, applied, adjusted, suggested, neurodegenerative, both group, community-based cohort study, 【제목키워드】 outcome, individual, cohort analysis, neurodegenerative,