Coronavirus disease 2019 (COVID-19) pandemic represents a scientific and social crisis. One of the main unmet needs for coronavirus disease 2019 is its unpredictable clinical course, which can rapidly change in an irreversible outcome. COVID-19 patients can be classified into mild, moderate, and severe. Several haematological parameters, such as platelets, white blood cell total count, lymphocytes, neutrophils, (together with neutrophil-lymphocyte and platelet-lymphocyte ratio), and haemoglobin were described to be associated with COVID-19 infection and severity. The purpose of these review is to describe the current state of the art about complete blood count alterations during COVID-19 infection, and to summarize the crucial role of some haematological parameters during the course of the disease. Decreased platelet, lymphocyte, haemoglobin, eosinophil, and basophil count, increased neutrophil count and neutrophil-lymphocyte and platelet-lymphocyte ratio have been associated with COVID-19 infection and a worse clinical outcome. Our study adds some novelty about the identification of effective biomarkers of progressive disease, and might be helpful for diagnosis, prevention of complications, and effective therapy.
【저자키워드】 Critical care, Haematology, COVID-19 virus disease, 【초록키워드】 COVID-19, coronavirus disease, Neutrophils, Coronavirus disease 2019, pandemic, Biomarker, Lymphocytes, severity, Infection, Diagnosis, Platelets, outcome, eosinophil, Clinical outcome, lymphocyte, Haemoglobin, Clinical course, White blood cell, COVID-19 infection, complete blood count, Platelet, Mild, complications, moderate, COVID-19 patient, unmet need, alteration, neutrophil count, effective therapy, progressive disease, haematological parameters, effective, Course, described, the disease, Decreased, haematological parameter, with COVID-19, 【제목키워드】 COVID-19, Blood, alteration,