We investigated nasopharyngeal microbial community structure in COVID-19-positive and -negative patients. High-throughput 16S ribosomal RNA gene amplicon sequencing revealed significant microbial community structure differences between COVID-19-positive and -negative patients. This proof-of-concept study demonstrates that: (1) nasopharyngeal microbiome communities can be assessed using collection samples already collected for SARS-CoV-2 testing (viral transport media) and (2) SARS-CoV-2 infection is associated with altered dysbiotic microbial profiles which could be a biomarker for disease progression and prognosis in SARS-CoV-2. Supplementary Information The online version contains supplementary material available at 10.1186/s12575-021-00148-6.
【저자키워드】 COVID-19, SARS-CoV-2, microbiota, nasopharyngeal, Dysbiosis, 【초록키워드】 Biomarker, Prognosis, SARS-COV-2 infection, Disease progression, SARS-CoV-2 testing, Microbiome, Community, viral transport media, microbial community, patients, Amplicon sequencing, microbial, supplementary material, profile, 16S ribosomal RNA, collected, investigated, 【제목키워드】 negative,