The novel coronavirus SARS-CoV-2 causes the disease COVID-19, a severe acute respiratory syndrome. COVID-19 is now a global pandemic and public health emergency due to rapid human-to-human transmission. The impact is far-reaching, with enforced social distancing and isolation, detrimental effects on individual physical activity and mental wellbeing, education in the young and economic impact to business. Whilst most COVID-19 patients demonstrate mild-to-moderate symptoms, those with severe disease progression are at a higher risk of mortality. As more is learnt about this novel disease, it is becoming evident that comorbid cardiovascular disease is associated with a greater severity and increased mortality. Many patients positive for COVID-19 demonstrate increased concentrations of cardiac troponin, creating confusion in clinical interpretation. While myocardial infarction is associated with acute infectious respiratory disease, the majority of COVID-19 patients demonstrate stable cTn rather than the dynamically changing values indicative of an acute coronary syndrome. Although full understanding of the mechanism of cTn release in COVID-19 is currently lacking, this mini-review assesses the limited published literature with a view to offering insight to pathophysiological mechanisms and reported treatment regimens.
【저자키워드】 COVID-19, SARS-CoV-2, troponin, Analytes, Cardiac troponin I, cardiac troponin T, 【초록키워드】 Mortality, physical activity, social distancing, severity, cardiovascular disease, Symptoms, cardiac troponin, global pandemic, Respiratory disease, Patient, Interpretation, Isolation, public health emergency, Myocardial infarction, disease, mechanism, Concentration, COVID-19 patient, Mild-to-moderate, Confusion, acute respiratory syndrome, higher risk, treatment regimens, novel coronavirus SARS-CoV-2, increased mortality, pathophysiological mechanism, human-to-human transmission, positive, while, severe disease progression, Mental, greater, reported, the disease, majority, cause, detrimental effect, coronary syndrome, creating, cTn, 【제목키워드】 cardiac troponin, COVID-19 infection, clinical, utility,