Severe coronavirus disease 2019 (COVID-19) causes a hyperactivation of immune cells, resulting in lung inflammation. Recent studies showed that COVID-19 induces the production of factors previously implicated in the reawakening of dormant breast cancer cells such as neutrophil extracellular traps (NETs). The presence of NETs and of a pro-inflammatory microenvironment may therefore promote breast cancer reactivation, increasing the risk of pulmonary metastasis. Further studies will be required to confirm the link between COVID-19 and cancer recurrence. However, an increased awareness on the potential risks for breast cancer patients with COVID-19 may lead to improved treatment strategies to prevent metastatic relapse.
【저자키워드】 COVID-19, Inflammation, Breast cancer, Metastasis, Relapse, dormancy, Disseminated tumor cells, Tumor recurrence, Metastatic reawakening, 【초록키워드】 coronavirus disease, Cancer, risk, Neutrophil extracellular trap, immune cells, NETs, Lung inflammation, treatment strategy, Factor, potential risk, Hyperactivation, microenvironment, pro-inflammatory, NET, recent, Prevent, Cell, breast cancer patient, resulting, required, promote, induce, cause, implicated, dormant, with COVID-19, 【제목키워드】 Immune-mediated,