Abstract At the end of 2019, respiratory coronavirus diseases 2019 (COVID‐19) appeared and spread rapidly in the world. Besides several mutations, the outcome of this pandemic was the death up to 15% of hospitalized patients. Mesenchymal stromal cell therapy as a therapeutic strategy seemed successful in treatment of several diseases. Not only mesenchymal stromal cells of several tissues, but also their secreted extracellular vesicles and even secretome indicated beneficial therapeutic function. All of these three options were studied for treatment of COVID‐19 as well as those respiratory diseases that have similar symptom. Fortunately, most of the outcomes were promising and optimistic. In this paper, we review in‐vivo and clinical studies which have been used different sources of mesenchymal stromal cell, secreted extracellular vesicles, and secretome to improve and treat symptoms of COVID‐19 and similar lung diseases. The main event of COVID‐19 infection and MSC‐Based treatment, In step1, viruses are present in patient’s lung and could infected others by dispersing of the virus particles (as an example by cough), then these particles enter into the body of healthy man (2), viruses bind to ACE2 receptor in cells of the respiratory system (3), symptoms could be different between patients from tolerable condition to intolerable states which the patient needs to be hospitalizing. These patients can make other people sick (4). MSC‐Based therapies include MSCs, MSC‐EVs, and MSC‐secretome (5) that are from four main sources including, adipose, bone marrow, menstrual blood, and umbilical cord (6). Results show the potential of these treatments in COVID‐19 recovery (7). The recovered body could be infected and receive viruses again (8).
【저자키워드】 COVID‐19, Extracellular vesicles, respiratory diseases, Mesenchymal stromal cell, Secretome, 【초록키워드】 Treatment, pandemic, therapy, Diseases, mutations, lung, ACE2 receptor, MSCs, Symptom, outcome, hospitalized patients, cough, Particle, COVID‐19, Bone marrow, Spread, Lung diseases, Respiratory disease, therapeutic, Patient, death, Respiratory system, extracellular vesicle, disease, therapeutic strategy, clinical study, stromal cell, tissues, treat, COVID‐19 infection, adipose, Cell, Respiratory Coronavirus, IMPROVE, Result, virus, example, include, healthy, indicated, the patient, virus particle, sick, receive, menstrual blood, secreted, tolerable, umbilical, 【제목키워드】 Lung disease, Symptom, COVID‐19, cellular, stromal cell,