Myocardial injury in hospitalized patients is associated with poor prognosis. This study aimed to evaluate risk factors for myocardial injury in hospitalized patients with coronavirus disease 2019 (COVID-19) and its prognostic value. We retrieved all consecutive patients who were hospitalized in internal medicine departments in a tertiary medical center from February 9 th , 2020 to August 28 th with a diagnosis of COVID-19. A total of 559 adult patients were hospitalized in the Sheba Medical Center with a diagnosis of COVID-19, 320 (57.24%) of whom were tested for troponin levels within 24-hours of admission, and 91 (28.44%) had elevated levels. Predictors for elevated troponin levels were age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.01–1.06), female sex (OR, 3.03; 95% CI 1.54–6.25), low systolic blood pressure (OR, 5.91; 95% CI 2.42–14.44) and increased creatinine level (OR, 2.88; 95% CI 1.44–5.73). The risk for death (hazard ratio [HR] 4.32, 95% CI 2.08–8.99) and a composite outcome of invasive ventilation support and death (HR 1.96, 95% CI 1.15–3.37) was significantly higher among patients who had elevated troponin levels. In conclusion, in hospitalized patients with COVID-19, elevated troponin levels are associated with poor prognosis. Hence, troponin levels may be used as an additional tool for risk stratification and a decision guide in patients hospitalized with COVID-19.
【초록키워드】 COVID-19, coronavirus disease, Coronavirus disease 2019, Risk factors, Hospitalized, Sex, risk, troponin, outcome, hospitalized patients, risk factor, invasive ventilation, risk stratification, myocardial injury, female, Patient, death, age, Admission, creatinine, internal medicine, Injury, Odds ratio, Support, Systolic blood pressure, Prognostic value, 95% CI, 95% confidence interval, hazard ratio, poor prognosis, troponin levels, center, tested, evaluate, elevated, hospitalized patient, significantly higher, consecutive patient, diagnosis of COVID-19, patients hospitalized, retrieved, troponin level, with COVID-19, 【제목키워드】 outcome, Injury, Factor, hospitalized patient, with COVID-19,