Diabetes mellitus (DM) has a high incidence of comorbidities among patients with severe coronavirus disease 2019 (COVID-19). The elevated prevalence of DM in the world population makes it a significant risk factor because diabetic individuals appear to be prone to clinical complications and have increased mortality rates. Here, we review the possible underlying mechanisms involved in DM that led to worse outcomes in COVID-19. The impacts of hyperglycemia side effects, secondary comorbidities, weakened innate and adaptive immunity, chronic inflammation, and poor nutritional status, commonly present in DM, are discussed. The role of the SARS-CoV-2 receptor and its polymorphic variations on higher binding affinity to facilitate viral uptake in people with DM were also considered. Clinical differences between individuals with type 1 DM and type 2 DM affected by COVID-19 and the potential diabetogenic effect of SARS-CoV-2 infection were addressed.
【저자키워드】 COVID-19, Diabetes Mellitus, SARS-CoV-2 receptor, chronic inflammation, impaired immune system, ACE2 polymorphisms, diabetogenic effect, 【초록키워드】 adaptive, Immunity, SARS-COV-2 infection, Variation, Comorbidities, Comorbidity, outcome, risk factor, binding affinity, Prevalence, clinical, Impact, Patient, receptor, incidence, Side effects, hyperglycemia, mechanism, nutritional status, Diabetic, severe coronavirus disease, individual, increased mortality, weakened, clinical complication, affected, involved, elevated, facilitate, addressed, the SARS-CoV-2, 【제목키워드】 severe COVID-19, progression, Critical, mechanism, diabete,