Background Novel coronavirus disease 2019 (COVID-19) has become a worldwide pandemic and precise fatality data by age group is needed urgently. This study to delineate the clinical characteristics and outcome of COVID-19 patients aged ≥75 years and identify the risk factors of in-hospital death. Methods A total of 141 consecutive patients aged ≥75 years who were admitted to the hospital between 12th and 19th February 2020. In-hospital death, clinical characteristics and laboratory findings on admission were obtained from medical records. The final follow-up observation was on the 31st March 2020. Results The median age was 81 years (84 female, 59.6%). Thirty-eight (27%) patients were classified as severe or critical cases. 18 (12.8%) patients had died in hospital and the remaining 123 were discharged. Patients who died were more likely to present with fever (38.9% vs. 7.3%); low percutaneous oxygen saturation (SpO 2 ) (55.6% vs. 7.3%); reduced lymphocytes (72.2% vs. 35.8%) and platelets (27.8% vs. 4.1%); and increased D-dimer (94.4% vs. 42.3%), creatinine (50.0% vs. 22.0%), lactic dehydrogenase (LDH) (77.8% vs. 30.1%), high sensitivity troponin I (hs-TnI) (72.2% vs. 14.6%), and N-terminal pro-brain natriuretic peptide (NT-proBNP) (72.2% vs. 6.5%; all P < 0.05) than patients who recovered. Male sex (odds ratio [OR] = 13.1, 95% confidence interval [CI] 1.1 to 160.1, P = 0.044), body temperature > 37.3 °C (OR = 80.5, 95% CI 4.6 to 1407.6, P = 0.003), SpO 2 ≤ 90% (OR = 70.1, 95% CI 4.6 to 1060.4, P = 0.002), and NT-proBNP> 1800 ng/L (OR = 273.5, 95% CI 14.7 to 5104.8, P < 0.0001) were independent risk factors of in-hospital death. Conclusions In-hospital fatality among elderly COVID-19 patients can be estimated by sex and on-admission measurements of body temperature, SpO 2 , and NT-proBNP. Supplementary Information The online version contains supplementary material available at 10.1186/s12877-020-01921-0.
【저자키워드】 coronavirus disease, SARS-CoV-2, elderly, prediction, death, 【초록키워드】 Clinical characteristics, hospital, peptide, LDH, Sex, D-dimer, outcome, risk factor, Laboratory, lymphocyte, oxygen saturation, sensitivity, Fever, female, Patient, Platelet, age, Follow-up, novel, troponin I, NT-proBNP, Admission, body temperature, fatality, creatinine, Odds ratio, COVID-19 patient, critical cases, medical records, lactic dehydrogenase, In-hospital death, observation, supplementary material, 95% CI, 95% confidence interval, median age, worldwide pandemic, Final, independent risk factor, hs-TNI, N-terminal, Result, identify, died, reduced, discharged, consecutive patient, 【제목키워드】 outcome, novel coronavirus disease, Characteristics, clinical, Patient, Admission, predict, In-hospital, retrospective cohort study,