Several therapeutic regimens for COVID-19 have been studied, such as combination antiviral therapies. We aimed to compare outcome of two types of combination therapies atazanavir/ritonavir (ATV/r) or lopinavir/ritonavir (LPV/r) plus hydroxychloroquine among COVID-19 patients. 108 patients with moderate and severe forms of COVID-19 were divided into two groups (each group 54 patients). One group received ATV/r plus hydroxychloroquine, and the other group received hydroxychloroquine plus LPV/r. Then, both groups were evaluated and compared for clinical symptoms, recovery rates, and complications of treatment regimens. Our findings showed a significant increase in bilirubin in ATV/r-receiving group compared to LPV/r receivers. There was also a significant increase in arrhythmias in the LPV/r group compared to the ATV/r group during treatment. Other findings including length of hospital stay, outcome, and treatment complications were not statistically significant. There is no significant difference between protease inhibitor drugs including ATV/r and LPV/r in the treatment of COVID-19 regarding clinical outcomes. However, some side effects such as hyperbilirubinemia and arrhythmia were significantly different by application of atazanavir or lopinavir.
【초록키워드】 COVID-19, Treatment, Hydroxychloroquine, Clinical symptoms, combination therapy, drug, outcome, clinical outcomes, arrhythmia, Protease inhibitor, therapeutic, Complication, Other, patients, COVID-19 patients, Combination, Bilirubin, Hospital stay, regimen, antiviral therapies, Side effect, no significant difference, significant increase, treatment regimens, significantly, evaluated, form, two group, statistically significant, both group, patients with moderate, 【제목키워드】 COVID-19,