Background Since the first diagnosed case of infection with the novel coronavirus (SARS-CoV-2), there has been a rapid spread of the disease with an increasing number of cases confirmed every day, as well as a rising death toll. An association has been reported between acute kidney injury (AKI) and mortality in patients infected with SARS-CoV-2. Therefore, our study was conducted to explore possible risk factors of AKI as well as whether AKI was a risk factor for worse outcome, especially mortality among patients with coronavirus disease (COVID-19). Methods We included all hospital admissions with confirmed or clinically diagnosed COVID-19 from January 29 to February 25, 2020. We collected demographic and epidemiological information, past medical history, symptoms, laboratory tests, treatments, and outcome data from electronic medical records. A total of 492 patients with diagnosed or clinically diagnosed COVID-19 were included in this study. Results The prevalence rate of AKI was 7.32%. Among the factors associated with AKI, males versus females (aOR 2.73), chronic kidney disease (aOR 42.2), hypertension (aOR 2.82), increased leucocytes (aOR 6.08), and diuretic use (aOR 7.89) were identified as independent risk factors for AKI among patients infected by SARS-CoV-2. There was a significant difference in hospital fees and death in patients with and without AKI ( p < 0.05). The mortality rate in patients with AKI was 63.9%. Conclusions AKI was widespread among patients with COVID-19. The risk factors of AKI in COVID-19 patients included sex, chronic kidney disease, hypertension, infection, and diuretic use. AKI may be associated with a worse outcome, especially mortality in COVID-19 patients.
【초록키워드】 COVID-19, coronavirus disease, SARS-CoV-2, Mortality, hospital, Infection, Sex, Laboratory tests, Acute kidney injury, Chronic kidney disease, outcome, risk factor, hypertension, Symptoms, Novel coronavirus, Spread, Prevalence, AKI, male, female, Patient, death, epidemiological, Hospital admission, mortality rate, electronic medical records, information, COVID-19 patients, association, COVID-19 patient, leucocyte, Factor, significant difference, independent risk factor, past medical history, widespread, Result, collected, reported, clinically, diagnosed, the disease, conducted, rising, infected with SARS-CoV-2, patients with AKI, patients with COVID-19, 【제목키워드】 Wuhan, with COVID-19,