In the article Analysis of the impact of antidepressants and other medications on COVID-19 infection risk in a chronic psychiatric in-patient cohort, Catherine L. Clelland and colleagues for the first time suggest a protective effect of antidepressants against infection with coronavirus disease 2019 (COVID-19) itself. During the observation period of the first wave of the pandemic in New York, more than 50% of patients in the psychiatric hospital studied were infected. From retrospective analysis of the hospital medical records, the authors found a significantly lower risk for infection in patients with antidepressant medication compared to treatment with other psychiatric drugs. The findings of a reduced infection incidence in patients who were already on antidepressant drug therapy underlines a preventive efficacy of antidepressants against COVID-19. Taken together with the prior obtained data of efficacy against deterioration of COVID-19 disease, this study adds a piece of evidence to the positive benefit-risk of antidepressants in repurposing condition against COVID-19.
【저자키워드】 COVID-19, repurposing, prevention, antidepressants, SSRI, 【초록키워드】 Treatment, coronavirus disease, Efficacy, pandemic, therapy, hospital, Infection, drugs, risk, COVID-19 disease, Cohort, Deterioration, Patient, Retrospective analysis, infection risk, incidence, medication, New York, First wave, protective effect, Evidence, medical records, Psychiatric, observation period, positive, significantly lower, were infected, reduced, medications on COVID-19, 【제목키워드】 Treatment, antidepressant,