The recent outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has impacted the world severely. The binding of the SARS-CoV-2 virus to the angiotensin-converting enzyme 2 (ACE2) and its intake by the host cell is a necessary step for infection. ACE2 has garnered widespread therapeutic possibility as it is entry/interactive point for SARS-CoV-2, responsible for coronavirus disease 2019 (COVID-19) pandemic and providing a critical regulator for immune modulation in various disease. Patients with suffering from cancer always being on the verge of being immune compromised therefore gaining knowledge about how SARS-CoV-2 viruses affecting immune cells in human cancers will provides us new opportunities for preventing or treating virus-associated cancers. Despite COVID-19 pandemic got center stage at present time, however very little research being explores, which increase our knowledge in context with how SARS-CoV-2 infection affect cancer a cellular level. Therefore, in light of the ACE-2 as an important contributor of COVID-19 global, we analyzed correlation between ACE2 and tumor immune infiltration (TIL) level and the type markers of immune cells were investigated in breast cancer subtypes by using TIMER database. Our findings shed light on the immunomodulatory role of ACE2 in the luminal A subtype which may play crucial role in imparting therapeutic resistance in this cancer subtype. Highlights • The recent outbreak of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has impacted the world severely. • The binding of the SARS-CoV-2 virus to the angiotensin-converting enzyme 2 (ACE2) and its intake of this complex by the host cell is a necessary step for infection. • We reported that the differential gene expression of ACE2 defines its pathological role in each molecular subtype of breast cancer differently. • Our analysis suggested that the expression of ACE2 gene may relate to immune function in luminal A subtype of breast cancer. • This study is much significant in context with current pandemic in which ACE2 inhibitors are widely used for the COVD-19 treatment.
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