Background Coronaviruses, members of the Coronavirinae subfamily in the Coronaviridae family, are enveloped and positive-stranded RNA viruses that infect animals and humans, causing intestinal and respiratory infections. Coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus, named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This disease appeared, for the first time (December 2019), in China and has spread quickly worldwide causing a large number of deaths. Considering the global threat, the World Health Organization (WHO) has declared, in March 2020, COVID-19 as a pandemic. Many studies suggest the great effect of the existing vaccines to protect against symptomatic cases of death by the COVID-19 virus. This paper, proposes to compare the main antigenic proteins sequences of the existing vaccines with Spike (S) protein of the SARS-CoV-2 genome. Our choice of S protein is justified by the major role that plays it in the receptor recognition and membrane fusion process based on an intelligent system. Herein, we focus on finding a correlation between S protein and compulsory vaccines in the countries that have a less death number by COVID-19 virus. In this work, we have used a combination of coding methods, signal processing, and bioinformatic techniques with the goal to localize the similar patterns between the S gene of the SARS-Cov-2 genome and 14 investigated vaccines. Results A total of 8 similar sequences which have a size more than 6 amino acids were identified. Further, these comparisons propose that these segments can be implicated in the immune response against COVID-19, which may explain the wide variation by country in the severity of this viral threat. Conclusions Our in silico study suggests a possible protective effect of Poliovirus, HIB, Hepatitis B, PCV10, Measles, Mumps, and Rubella (MMR) vaccines against COVID-19.
【저자키워드】 COVID-19, coronavirus, Vaccines, hepatitis B, Poliovirus, HIB, And PCV10, Genome signature, Genomic coding techniques, 【초록키워드】 respiratory infections, SARS-CoV-2, Coronavirus disease 2019, Vaccine, immune response, pandemic, S protein, spike, severity, Variation, Genome, in silico, coronavirus 2, Novel coronavirus, Spread, China, Protein, humans, comparison, death, COVID-19 virus, WHO, membrane fusion, receptor, respiratory, correlation, disease, protective effect, Amino acid, measles, Combination, S gene, deaths, MMR, rubella, World Health Organization, sequence, coding, symptomatic case, infect, country, intestinal, PROTECT, Result, caused, investigated, RNA virus, antigenic protein, less, implicated, explain, the Coronaviridae, the SARS-CoV-2 genome, 【제목키워드】 Vaccine, SARS-CoV-2 spike protein, Analysis, antigenic protein,