As COVID-19 continues to spread worldwide, severe disease and mortality have been observed in obese patients. We discuss how obesity and obesity-associated factors such as ‘meta-flammation’, dietary fat intake and paradoxical suppression of the innate immune response within the pulmonary compartment may be crucial determinants in the host response to a novel viral pathogen. Modulation of immune cell bioenergetics and metabolic potential plays a central role in the innate immune response to infection, and as we strive to combat this new global health threat, immunometabolism of the innate immune system warrants attention.
All Keywords
【저자키워드】 COVID-19, obesity, immunometabolism, IL-1β inflammation, 【초록키워드】 Mortality, innate immune response, Infection, host response, innate immune system, Spread, Health, Immune cell, severe disease, determinant, Factor, obese patients, viral pathogen, fat, paradoxical,
【저자키워드】 COVID-19, obesity, immunometabolism, IL-1