Three major human coronavirus disease outbreaks, severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) and 2019 coronavirus disease (COVID-19), occurred in the twenty-first century and were caused by different coronaviruses (CoVs). All these viruses are considered to have originated from bats and transmitted to humans through intermediate hosts. SARS-CoV-1 and SARS-CoV-2, disease agent of COVID-19, shared around 80% genomic similarity, and thus belong to SARS-related CoVs. As a natural reservoir of viruses, bats harbor numerous other SARS-related CoVs that could potentially infect humans around the world, causing SARS or COVID-19 like outbreaks in the future. In this review, we summarized the current knowledge of CoVs on geographical distribution, genetic diversity, cross-species transmission potential and possible pathogenesis in humans, aiming for a better understanding of bat SARS-related CoVs in the context of prevention and control.
【저자키워드】 bat, spillover, cross-species, geographical distribution, SARS-related coronavirus, 【초록키워드】 COVID-19, coronavirus disease, viruses, SARS-CoV-2, coronavirus, Pathogenesis, knowledge, Human, MERS, virus, SARS-CoV-1, Outbreaks, outbreak, humans, 2019 coronavirus disease, CoV, genetic diversity, genomic, disease, Cross-species transmission, similarity, Middle East, acute respiratory syndrome, syndrome, CoVs, hosts, infect, SARS-related CoV, occurred, caused, transmitted, 【제목키워드】 coronavirus, acute respiratory syndrome,