The severe acute respiratory syndrome coronavirus-2 emerged as a serious human pathogen in late 2019, causing the disease coronavirus disease 2019 (COVID-19). The most common clinical presentation of severe COVID-19 is acute respiratory failure consistent with the acute respiratory distress syndrome. Airway, lung parenchymal, pulmonary vascular, and respiratory neuromuscular disorders all feature in COVID-19. This article reviews what is known about the effects of severe acute respiratory syndrome coronavirus-2 infection on different parts of the respiratory system, clues to understanding the underlying biology of respiratory disease, and highlights current and future translation and clinical research questions. Graphic Abstract: A graphic abstract is available for this article.
【저자키워드】 COVID-19, acute respiratory distress syndrome, Infection, Thromboembolism, Respiratory system, Diaphragm, 【초록키워드】 coronavirus disease, Respiratory failure, severe COVID-19, translation, lung, Respiratory disease, Research, acute respiratory distress, Coronavirus-2, acute respiratory syndrome, Vascular, Abstract, syndrome, human pathogen, disorder, Effect, highlight, the disease, parenchymal, 【제목키워드】 clinical, respiratory, Future, System, current,