Background Macrophage activation syndrome (MAS) is a rare multiorgan system disorder that may present as a fatal complication of underlying rheumatological disease, including dermatomyositis. Case presentation Here, we report the case of a 65-year-old Caucasian female with a history of psoriasis and a recent diagnosis of Coronavirus disease 2019 (COVID-19) who presented with progressive generalized weakness, joint pains, an erythematous rash, shortness of breath, and weight loss. She was ultimately diagnosed with biopsy-confirmed melanoma differentiation-associated protein 5 (MDA5)-positive dermatomyositis complicated by MAS, requiring intravenous immunoglobulin and high-dose methylprednisolone. Conclusions This report serves as a clinical reminder of the rare, yet clinically relevant association between MDA5-positive dermatomyositis and MAS, as well as highlights the potential contribution of other immune system activating diseases, such as COVID-19, associated with a cytokine storm and hyperinflammatory state.
【저자키워드】 COVID-19 infection, macrophage activation syndrome, dermatomyositis, 【초록키워드】 COVID-19, Coronavirus disease 2019, Intravenous immunoglobulin, Cytokine storm, Diseases, Diagnosis, immune system, Protein, female, Melanoma, disease, Rash, Multiorgan, association, hyperinflammatory state, Shortness of breath, weight loss, Activation, syndrome, weakness, fatal complication, high-dose methylprednisolone, disorder, rheumatological, highlight, joint, clinically, diagnosed, activating, erythematous, 【제목키워드】 MDA5, Activation, syndrome,