Background The recurrence of positive SARS-CoV-2 nucleic acid test results in patients with COVID-19 is becoming more important and warrants more attention. Case presentation This study reports 2 cases, a child with mild COVID-19 and an adult female with moderate COVID-19, who were discharged after three consecutive negative nucleic acid tests and were later readmitted to the hospital for recurrence of SARS-CoV-2 nucleic acid positivity. By tracking the patients’ symptoms, serum antibodies, and imaging manifestations after readmission, we found that they showed a trend of gradual improvement and recovery throughout treatment. They were cured without additional treatment, with the appearance of antibodies and the recovery of immune functions. Conclusions It is deemed extremely necessary to improve the discharge standard of care. At the same time, nucleic acid detection is recommended to increase the dynamic monitoring of serum antibodies and imaging, strengthen the management of discharged patients, and appropriately extend the home or centralized isolation time. Supplementary Information The online version contains supplementary material available at 10.1186/s12890-020-01348-8.
【저자키워드】 Coronavirus disease-19 (COVID-19), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), nucleic acid test, recurrence, 【초록키워드】 COVID-19, Treatment, antibody, hospital, discharged patients, Symptoms, discharge, Moderate COVID-19, Nucleic acid detection, management, female, Isolation, Mild, serum antibody, readmission, manifestation, Standard of care, supplementary material, SARS-CoV-2 nucleic acid, serum antibodies, positive, immune functions, IMPROVE, discharged, cured, patients with COVID-19, 【제목키워드】 Patient, SARS-CoV-2 nucleic acid, Positive test,