Abstract. Approximately 20% of patients infected with SARS-CoV-2 (COVID-19) develop potentially life-threatening pathologies involving hyperinflammation, cytokine storm, septic shock complications, coagulation dysfunction, and multiple organ failure. Blood levels of the prototypic acute phase reactant, C-reactive protein (CRP), which is hepatically synthesized and released in response to interleukin-6 stimulation, is markedly elevated in patients with COVID-19. Markedly high CRP levels correlate with poor prognosis for survival. Insights into CRP structure–function relationships have uncovered both pro- and anti-inflammatory isoforms that may be used to monitor the extent of tissue damage associated with COVID-19 pathologies and prognoses. Herein, rationale is given for interpretation of CRP blood levels as a simple, rapid, and cost-effective way to assess disease severity and help guide therapeutic options in COVID-19 patients.
【초록키워드】 COVID-19, pathology, Cytokine storm, Anti-inflammatory, disease severity, interleukin-6, C-reactive protein, CRP, survival, hyperinflammation, Patient, Interpretation, Septic shock, complications, multiple organ failure, COVID-19 patients, Blood level, therapeutic option, coagulation dysfunction, tissue damage, acute phase, poor prognosis, help, CRP level, MONITOR, isoform, insight, develop, elevated, released, infected with SARS-CoV-2, patients with COVID-19, potentially life-threatening, with COVID-19, 【제목키워드】 COVID-19, index, insight,