Background Observational studies suggest poorer glycemic traits and type 2 diabetes associated with coronavirus disease 2019 (COVID-19) risk although these findings could be confounded by socioeconomic position. We conducted a two-sample Mendelian randomization to clarify their role in COVID-19 risk and specific COVID-19 phenotypes (hospitalized and severe cases). Method We identified genetic instruments for fasting glucose ( n = 133,010), 2 h glucose ( n = 42,854), glycated hemoglobin ( n = 123,665), and type 2 diabetes (74,124 cases and 824,006 controls) from genome wide association studies and applied them to COVID-19 Host Genetics Initiative summary statistics (17,965 COVID-19 cases and 1,370,547 population controls). We used inverse variance weighting to obtain the causal estimates of glycemic traits and genetic predisposition to type 2 diabetes in COVID-19 risk. Sensitivity analyses included MR-Egger and weighted median method. Results We found genetic predisposition to type 2 diabetes was not associated with any COVID-19 phenotype (OR: 1.00 per unit increase in log odds of having diabetes, 95%CI 0.97 to 1.04 for overall COVID-19; OR: 1.02, 95%CI 0.95 to 1.09 for hospitalized COVID-19; and OR: 1.00, 95%CI 0.93 to 1.08 for severe COVID-19). There were no strong evidence for an association of glycemic traits in COVID-19 phenotypes, apart from a potential inverse association for fasting glucose albeit with wide confidence interval. Conclusion We provide some genetic evidence that poorer glycemic traits and predisposition to type 2 diabetes unlikely increase the risk of COVID-19. Although our study did not indicate glycemic traits increase severity of COVID-19, additional studies are needed to verify our findings. Supplementary Information The online version contains supplementary material available at 10.1186/s12916-021-01944-3.
【저자키워드】 COVID-19, mendelian randomization, type 2 diabetes, Glucose, glycated hemoglobin, 【초록키워드】 coronavirus disease, Hospitalized, severe COVID-19, Genome, Genetic, risk, diabetes, observational study, severity of COVID-19, severe cases, hemoglobin, estimate, association, Evidence, Analysis, Genetic predisposition, confidence interval, supplementary material, 95%CI, COVID-19 case, predisposition, weighted median, initiative, MR-Egger, Weighting, risk of COVID-19, controls, fasting glucose, COVID-19 phenotypes, COVID-19 phenotype, log, Result, conducted, unlikely, applied, increase in, genetic instrument, glycemic, type 2 diabete, 【제목키워드】 susceptibility, glycemic,