Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global pandemic threat with more than 11.8 million confirmed cases and more than 0.5 million deaths as of 3 July 2020. Given the lack of definitive pharmaceutical interventions against SARS-CoV-2, multiple therapeutic strategies and personal protective applications are being used to reduce the risk of high mortality and community spread of this infection. Currently, more than a hundred vaccines and/or alternative therapeutic regimens are in clinical trials, and some of them have shown promising results in improving the immune cell environment and controlling the infection. In this review, we discussed high-performance multi-directory strategies describing the uncontrolled deregulation of the host immune landscape associated with coronavirus disease (COVID-19) and treatment strategies using an anti-neoplastic regimen. We also followed selected current treatment plans and the most important on-going clinical trials and their respective outcomes for blocking SARS-CoV-2 pathogenesis through regenerative medicine, such as stem cell therapy, chimeric antigen receptors, natural killer (NK) cells, extracellular vesicular-based therapy, and others including immunomodulatory regimens, anti-neoplastic therapy, and current clinical vaccine therapy.
【저자키워드】 COVID-19, Cytokine storm, Mesenchymal stem cells, Extracellular vesicles, immunomodulatory drugs, adoptive cell-based therapy, anti-neoplastic regimen, 【초록키워드】 Treatment, coronavirus disease, SARS-CoV-2, Vaccine, coronavirus, clinical trial, therapy, Infection, clinical trials, risk, outcome, immune, Antigen, global pandemic, Spread, cells, immunomodulatory, therapeutic, death, Community, Stem cell therapy, receptors, SARS-CoV-2 pathogenesis, regenerative, therapeutic strategy, Protective, Immune cell, treatment strategy, chimeric, regimen, natural killer, confirmed case, acute respiratory syndrome, high mortality, regimens, deregulation, Host, Extracellular, selected, shown, lack, caused, reduce, pharmaceutical intervention, 【제목키워드】 race, modality, Multiple, running, uncontrolled, the SARS-CoV-2,