Simple Summary The current coronavirus disease 2019 pandemic turned the attention of researchers to developing novel strategies to counteract virus infections. Despite several antiviral drugs being commercially available, there is an urgent need to identify novel molecules efficacious against viral infections that act through different mechanisms of action. In this context, our attention is focused on novel compounds acting on nuclear receptors, whose activity could be beneficial in viral infections, including coronavirus, hepatitis C virus, and cytomegalovirus. Abstract The manipulation of host metabolisms by viral infections has been demonstrated by several studies, with a marked influence on the synthesis and utilization of glucose, nucleotides, fatty acids, and amino acids. The ability of virus to perturb the metabolic status of the infected organism is directly linked to the outcome of the viral infection. A great deal of research in recent years has been focusing on these metabolic aspects, pointing at modifications induced by virus, and suggesting novel strategies to counteract the perturbed host metabolism. In this review, our attention is turned on PPARs, nuclear receptors controlling multiple metabolic actions, and on the effects played by PPAR ligands during viral infections. The role of PPAR agonists and antagonists during SARS-CoV-2, HCV, and HCMV infections will be analyzed.
【저자키워드】 SARS-CoV-2, viral infection, HCV, antiviral drug, lipid metabolism, HCMV, PPAR, 【초록키워드】 coronavirus disease, coronavirus, pandemic, Infection, outcome, virus, viral infections, metabolism, infections, hepatitis C virus, Research, amino acids, Nuclear receptors, mechanism, Glucose, Ligand, nucleotides, fatty acids, nuclear receptor, Compound, organism, agonist, Modification, researcher, simple, antagonist, Host, Effect, analyzed, identify, in viral, demonstrated, acting, novel molecule, 【제목키워드】 Lipid, targeting, Effect,