Non-conductive olfactory dysfunction (OD) is an important extra-pulmonary manifestation of coronavirus disease 2019 (COVID-19). Olfactory bulb (OB) volume loss and olfactory network functional connectivity (FC) defects were identified in two patients suffering from prolonged COVID-19-related OD. One patient received olfactory treatment (OT) by the combination of oral vitamin A and smell training via the novel electronic portable aromatic rehabilitation (EPAR) diffusers. After four-weeks of OT, clinical recuperation of smell was correlated with interval increase of bilateral OB volumes [right: 22.5 mm 3 to 49.5 mm 3 (120%), left: 37.5 mm 3 to 42 mm 3 (12%)] and improvement of mean olfactory FC [0.09 to 0.15 (66.6%)].
【저자키워드】 COVID-19, olfactory dysfunction, vitamin A, smell training, resting-state fMRI, 【초록키워드】 Treatment, coronavirus disease, rehabilitation, olfactory bulb, Patient, Combination, olfactory, Volume, one patient, functional, correlated, 【제목키워드】 network, Neurosensory,