In this review we attempt to collate the existing scientific evidence regarding the possible role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the pathophysiology of Parkinson’s disease (PD), as well as to investigate the impact of PD/parkinsonism on the clinical course of the viral infection itself. Since etiology of PD is not completely understood, various studies suggest different potential links between coronavirus disease 2019 (COVID-19) and PD. Suggested connections include, among others, similar prodromal symptoms, renin–angiotensin–aldosterone system involvement, or gut microbiome dysbiosis participation. Despite the initial assumptions that, as a mainly elderly population suffering from rigidity of respiratory muscles, impairment of cough reflex, and dyspnea, PD patients would be more susceptible to viral infection, and would experience a more aggressive course of COVID-19, the published scientific reports contain mutually exclusive data that require further investigation and meta-analysis.
【저자키워드】 COVID-19, SARS-CoV-2, Parkinson’s disease, Parkinsonism, 【초록키워드】 coronavirus disease, Meta-analysis, viral infection, coronavirus, cough, Symptoms, Clinical course, pathophysiology, Dyspnea, Patient, Microbiome, etiology, Evidence, Parkinson’s disease, Gut, connection, acute respiratory syndrome, rigidity, assumption, impairment, muscles, susceptible, initial, Course, include, 【제목키워드】 LIGHT,