The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a neurotropic virus with a high neuroinvasive potential. Indeed, more than one-third of patients develop neurological symptoms, including confusion, headache, and hypogeusia/ageusia. However, long-term neurological consequences have received little interest compared to respiratory, cardiovascular, and renal manifestations. Several mechanisms have been proposed to explain the potential SARS-CoV-2 neurological injury that could lead to the development of neurodegenerative diseases, including Alzheimer’s Disease (AD). A mutualistic relationship between AD and COVID-19 seems to exist. On the one hand, COVID-19 patients seem to be more prone to developing AD. On the other hand, AD patients could be more susceptible to severe COVID-19. In this review, we sought to provide an overview on the relationship between AD and COVID-19, focusing on the potential role of biomarkers, which could represent precious tool for early identification of COVID-19 patients at high risk of developing AD.
【저자키워드】 SARS-CoV-2, Biomarkers, Neuroinflammation, nervous system, AD, neurodegenerative nisease, 【초록키워드】 COVID-19, Diseases, severe COVID-19, headache, virus, coronavirus 2, Patient, Manifestations, Neurological symptoms, respiratory, mechanism, Injury, neurological, COVID-19 patient, Neuroinvasive, high risk, Confusion, renal, susceptible, consequence, neurotropic, develop, explain, neurodegenerative, 【제목키워드】 COVID-19,