Background: Severe Acute Respiratory Syndrome-coronavirus 2 (SARS-CoV-2) is a new virus with a global pandemic. Yet, no vaccine or efficient treatments are found against the disease. The viral RNA dependent RNA Polymerase (RdRP) is a suitable target for developing antiviral agents. SARS-CoV-2 RdRP was employed to test its binding activity with some drugs. Methods: Using some docking methods, RdRP was targeted by Milbemycins (MMs), Ivermectin (IMT), Baloxavir Marboxil (BM), and Tadalafil (TF), a phosphodiesterase type 5 inhibitor. Results: MM-A3 5-oxime (MMA35O), MM-A3 (MMA3), MM-A4 5-oxime (MMA45O), IMT, BM, and TF showed the highest binding affinity to RdRp. Conclusion: The drugs used in the present computational investigation are effective against the SARS-CoV-2 RdRP with high affinity values especially, milbemycins, ivermectin, and Baloxavir marboxil, which could further be studied in laboratory and clinical trials for saving millions of lives around the world.
【저자키워드】 COVID-19, Ivermectin, baloxavir, Tadalafil, 【초록키워드】 Treatment, SARS-CoV-2, Vaccine, clinical trial, drugs, drug, docking, Laboratory, RNA, global pandemic, Antiviral agents, RdRP, Viral RNA, respiratory, inhibitor, binding activity, baloxavir marboxil, highest binding affinity, high affinity, new virus, effective, the disease, Milbemycin, the SARS-CoV-2, 【제목키워드】 drug, RNA, Dependent, Milbemycin,