Development of new medicines for malaria is a challenging and important topic of applied research because malarial parasites rapidly adapt to man-made interventions. Best studied examples are widely used drugs such as chloroquine, sulfadoxin-pyrimethamine (SP), and, recently, artemisinins; all of them can lose efficacy after large-scale introduction. In addition to drugs, malaria vaccines re-emerged on the agenda of funding bodies and research institutions after a period of quietness and desperation. This time the communities’ aims are high: a registered and effective malaria-vaccine. So far, only one candidate shows modest efficacy, a quantum leap in malaria vaccine research, whereas others have not met the high expectations. In this overview, I will summarize basic thoughts and principles behind our work and illustrate them with examples of current projects of my group.
New medicines for malaria
[Category] 말라리아,
[Article Type] article
[Source] pubmed
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