Background Symptomatic severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection incidence is higher in the elderly patients. Pre-existing geriatric conditions such as comorbidity and frailty seem related to worse hospital outcomes. Aims To assess the role of nutritional status as an independent prognostic factor for in-hospital death in elderly patients. Methods Consecutive elderly patients (age > 65 years) hospitalized for novel coronavirus disease (COVID-19) were enrolled. Demographics, laboratory and comorbidity data were collected. Nutritional status was evaluated using the Geriatric Nutritional Risk Index (GNRI). Uni- and multivariate Cox regression analyses to evaluate predictors for in-hospital death were performed. Results One hundred and nine hospitalized elderly patients (54 male) were consecutively enrolled. At univariate analysis, age (HR 1.045 [CI 1.008–1.082]), cognitive impairment (HR 1.949 [CI 1.045–3.364]), C-reactive protein (HR 1.004 [CI 1.011–1.078]), lactate dehydrogenases (HR 1.003 [CI 1.001–1.004]) and GNRI moderate–severe risk category (HR 8.571 [CI 1.096–67.031]) were risk factors for in-hospital death, while albumin (HR 0.809 [CI 0.822–0.964]), PaO 2 /FiO 2 ratio (HR 0.996 [CI 0.993–0.999]) and body mass index (HR 0.875 [CI 0.782–0.979]) were protective factors. Kaplan–Meier survival curves showed a significative higher survival in patients without GNRI moderate or severe risk category ( p = 0.0013). At multivariate analysis, PaO 2 /FiO 2 ratio (HR 0.993 [CI 0.987–0.999], p = 0.046) and GNRI moderate–severe risk category (HR 9.285 [1.183–72.879], p = 0.034) were independently associated with in-hospital death. Conclusion Nutritional status assessed by GNRI is a significative predictor of survival in elderly patients hospitalized for COVID-19. The association between GNRI and PaO 2 /FiO 2 ratio is a good prognostic model these patients.
【저자키워드】 COVID-19, nutrition, elderly, Geriatric nutritional risk index, 【초록키워드】 SARS-CoV-2, Hospitalized, hospital, Infection, frailty, Comorbidity, C-reactive protein, novel coronavirus disease, risk factor, elderly patients, lactate dehydrogenase, Laboratory, outcomes, body mass index, survival, male, Patient, albumin, Factors, Cognitive impairment, age, predictor, incidence, moderate, patients, Protective, association, Analysis, Elderly patient, nutritional status, Prognostic factor, In-hospital death, prognostic model, index, multivariate Cox regression, Univariate analysis, independent, Risk category, Result, enrolled, performed, collected, evaluate, evaluated, nine, condition, Kaplan–Meier survival curve, PaO, 【제목키워드】 Hospitalized, Elderly patient, nutritional status,