Mortality and morbidity associated with COVID-19 continue to be significantly high worldwide, owing to the absence of effective treatment strategies. The emergence of different variants of SARS-CoV-2 is also a considerable source of concern and has led to challenges in the development of better prevention and treatment strategies, including vaccines. Immune dysregulation due to pro-inflammatory mediators has worsened the situation in COVID-19 patients. Inflammasomes play a critical role in modulating pro-inflammatory cytokines in the pathogenesis of COVID-19 and their activation is associated with poor clinical outcomes. Numerous preclinical and clinical trials for COVID-19 treatment using different approaches are currently underway. Targeting different inflammasomes to reduce the cytokine storm, and its associated complications, in COVID-19 patients is a new area of research. Non-coding RNAs, targeting inflammasome activation, may serve as an effective treatment strategy. However, the efficacy of these therapeutic agents is highly dependent on the delivery system. MicroRNAs and long non-coding RNAs, in conjunction with an efficient delivery vehicle, present a potential strategy for regulating NLRP3 activity through various RNA interference (RNAi) mechanisms. In this regard, the use of nanomaterials and other vehicle types for the delivery of RNAi-based therapeutic molecules for COVID-19 may serve as a novel approach for enhancing drug efficacy. The present review briefly summarizes immune dysregulation and its consequences, the roles of different non-coding RNAs in regulating the NLRP3 inflammasome, distinct types of vectors for their delivery, and potential therapeutic targets of microRNA for treatment of COVID-19.
【저자키워드】 COVID-19, Molecular targets, RNA interference, Non-coding RNAs, Inflammasome, 【초록키워드】 Treatment, Efficacy, clinical trial, Vaccines, microRNA, RNAs, NLRP3 inflammasome, clinical outcomes, Consequences, vector, morbidity, Research, complications, therapeutic agent, mechanisms, Critical, COVID-19 patients, NLRP3, COVID-19 patient, immune dysregulation, dysregulation, Drug efficacy, Activation, Treatment strategies, Therapeutic molecule, pathogenesis of COVID-19, inflammasome activation, pro-inflammatory cytokine, potential therapeutic target, targeting, non-coding RNA, variants of SARS-CoV-2, approach, effective, approach, significantly, absence, dependent on, reduce, Numerous, modulating, pro-inflammatory mediator, the cytokine storm, with COVID-19, worsened, 【제목키워드】 RNA, delivery, molecule, targeting,