The endothelium controls vascular homeostasis through a delicate balance between secretion of vasodilators and vasoconstrictors. The loss of physiological homeostasis leads to endothelial dysfunction, for which inflammatory events represent critical determinants. In this context, therapeutic approaches targeting inflammation-related vascular injury may help for the treatment of cardiovascular disease and a multitude of other conditions related to endothelium dysfunction, including COVID-19. In recent years, within the complexity of the inflammatory scenario related to loss of vessel integrity, hydrogen sulfide (H 2 S) has aroused great interest due to its importance in different signaling pathways at the endothelial level. In this review, we discuss the effects of H 2 S, a molecule which has been reported to demonstrate anti-inflammatory activity, in addition to many other biological functions related to endothelium and sulfur-drugs as new possible therapeutic options in diseases involving vascular pathobiology, such as in SARS-CoV-2 infection.
【저자키워드】 COVID-19, SARS-CoV-2, Inflammation, Endothelium, therapeutic target, Hydrogen sulfide, 【초록키워드】 Treatment, SARS-COV-2 infection, cardiovascular disease, anti-inflammatory activity, Endothelial dysfunction, biological function, Control, signaling pathway, determinants, disease, Critical, homeostasis, Therapeutic approach, Inflammatory, physiological, therapeutic option, dysfunction, Vascular injury, endothelial, Vascular, secretion, help, vascular homeostasis, Effect, vessel, event, reported, addition, condition, 【제목키워드】 bridge,