Objective: To describe the capacity of a broad spectrum of cytokines and growth factors to predict ICU admission and/or death in patients with severe COVID-19. Design: An observational, analytical, retrospective cohort study with longitudinal follow-up. Setting: Hospital Universitario Príncipe de Asturias (HUPA). Participants: 287 patients diagnosed with COVID-19 admitted to our hospital from 24 March to 8 May 2020, followed until 31 August 2020. Main outcome measures: Profiles of immune response (IR) mediators were determined using the Luminex Multiplex technique in hospitalized patients within six days of admission by examining serum levels of 62 soluble molecules classified into the three groups: adaptive IR-related cytokines ( n = 19), innate inflammatory IR-related cytokines ( n = 27), and growth factors ( n = 16). Results: A statistically robust link with ICU admission and/or death was detected for increased serum levels of interleukin (IL)-6, IL-15, soluble (s) RAGE, IP10, MCP3, sIL1RII, IL-8, GCSF and MCSF and IL-10. The greatest prognostic value was observed for the marker combination IL-10, IL-6 and GCSF. Conclusions: When severe COVID-19 progresses to ICU admission and/or death there is a marked increase in serum levels of several cytokines and chemokines, mainly related to the patient’s inflammatory IR. Serum levels of IL-10, IL-6 and GCSF were most prognostic of the outcome measure.
【저자키워드】 COVID-19, SARS-CoV-2, Cytokines, ICU, innate inflammatory response, 【초록키워드】 immune response, adaptive, severe COVID-19, IL-6, RAGE, hospital, cytokine, chemokines, outcome, Patient, ICU admission, death, IL-8, Follow-up, IL-10, prognostic, Admission, predict, IL-15, marker, IP10, Combination, Inflammatory, retrospective cohort study, Prognostic value, Serum level, profile, outcome measure, growth factor, GCSF, robust, hospitalized patient, increase in, statistically, Asturia, diagnosed with COVID-19, 【제목키워드】 response, Impact, Innate, with COVID-19,