An early analysis of circulating monocytes may be critical for predicting COVID-19 course and its sequelae. In 131 untreated, acute COVID-19 patients at emergency room arrival, monocytes showed decreased surface molecule expression, including low HLA-DR, in association with an inflammatory cytokine status and limited anti-SARS-CoV-2-specific T cell response. Most of these alterations had normalized in post-COVID-19 patients 6 months after discharge. Acute COVID-19 monocytes transcriptome showed upregulation of anti-inflammatory tissue repair genes such as BCL6 , AREG and IL-10 and increased accessibility of chromatin. Some of these transcriptomic and epigenetic features still remained in post-COVID-19 monocytes. Importantly, a poorer expression of surface molecules and low IRF1 gene transcription in circulating monocytes at admission defined a COVID-19 patient group with impaired SARS-CoV-2-specific T cell response and increased risk of requiring intensive care or dying. An early analysis of monocytes may be useful for COVID-19 patient stratification and for designing innate immunity-focused therapies.
【저자키워드】 COVID-19, Transcriptome, HLA-DR, circulating monocytes, chromatin accessibility, 【초록키워드】 Stratification, Monocytes, intensive care, Anti-inflammatory, Transcription, discharge, monocyte, Patient, IL-10, expression, Epigenetic, Admission, Critical, IRF1, T cell response, tissue repair, Inflammatory cytokine, Therapies, association, Analysis, COVID-19 patient, Bcl6, increased risk, alteration, upregulation, acute COVID-19, chromatin, MOST, transcriptomic, feature, Course, defined, remained, AREG, circulating monocyte, normalized, post-COVID-19 patient, surface molecule, 【제목키워드】 alteration, Month, Still,